Growth Differentiation Factor 15 and Coronary Collateral Formation
نویسندگان
چکیده
منابع مشابه
GDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
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Background—Growth-differentiation factor-15 (GDF-15) is a stress-responsive transforming growth factor-related cytokine that has emerged as a prognostic biomarker in acute coronary syndrome trial populations. Its predictive role in stable coronary heart disease (CHD) has never been assessed. Methods and Results—The circulating levels of GDF-15 were measured by immunoradiometric assay in patient...
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Collateral Formation To the Editor: In their excellent special review article on coronary collaterals, Koerselman et al1 outline the angiogenic cascade and discuss why coronary collaterals are important and why this individual potential to develop collaterals should be considered an additional indicator of cardiac vulnerability. However, the authors do not emphasize the importance of the geneti...
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BACKGROUND Recent studies have shown Growth differentiation factor-15 (GDF-15) that is a member of the transforming growth factor β (TGF-β) superfamily might be a potential predictive cytokine for the prognosis of Acute coronary syndrome (ACS). However, there are discrepancies in these studies. METHODS Publication searches of the PubMed/Medline and EMBASE databases were performed without any ...
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It has been 50 years since Dr. William B. Kannel coined the term “factors of risk” in relation to cardiovascular disease (1). Since then, clinical risk assessment, including the use of circulating biomarkers, has become an integral part of medical practice. The current era of genomics, proteomics, and metabolomics is projected to lead to the discovery of an immense number of novel candidate bio...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 2009
ISSN: 0160-9289
DOI: 10.1002/clc.20698